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NHS PREDICT Breast Cancer Prognostic Model

PREDICT is the NHS-developed prognostic model that estimates overall and breast cancer-specific survival at 5 and 10 years, with and without adjuvant therapy, for early invasive breast cancer.

Purpose:
Estimate survival benefit of adjuvant chemotherapy, endocrine therapy, and trastuzumab
Population:
Women with early invasive breast cancer (operable, non-metastatic)
Factors:
Age, Tumour size, Tumour grade, Positive nodes, ER status, HER2 status, KI-67, Detection method
Reference:
Wishart et al., Breast Cancer Research 2010; PREDICT v2.2
HomePREDICT Breast (Prognostic Index)
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PREDICT Breast (Prognostic Index)

years
mm

Clinical Context & Background

PREDICT Breast is a prognostication tool for early invasive breast cancer. It estimates the survival benefit of adjuvant chemotherapy, endocrine therapy, and trastuzumab. This calculator computes the baseline Prognostic Index (PI), which correlates with overall survival risk.
Primary Source EvidenceCandido Dos Reis FJ, Wishart GC, Dicks EM, et al. An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation. Breast Cancer Res. 2017;19(1):58.
Formula Logic
PI based on Age, Size, Grade, Nodes, ER, HER2, Ki67, and Mode of Detection.

Reference Data

Prognostic Index (PI)Risk Level
Lower PIBetter Survival Probability
Higher PIWorse Survival Probability

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