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Leibovich Score for Renal Cell Carcinoma

The Leibovich score predicts metastasis-free survival after nephrectomy for clear cell renal cell carcinoma using pathological variables from the surgical specimen.

Purpose:
Predict progression to metastatic disease after nephrectomy for ccRCC
Population:
Patients with clear cell RCC who have undergone nephrectomy with no metastases at surgery
Factors:
Pathological T stage, Regional lymph node status, Tumour size, Nuclear grade, Histologic tumour necrosis
Reference:
Leibovich et al., Cancer 2003
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Leibovich Score (RCC)

Clinical Context & Background

The Leibovich Score (2003) is a standard prognostic model for patients with non-metastatic clear cell renal cell carcinoma (ccRCC) who have undergone radical nephrectomy. It uses pathologic T-stage, N-stage, tumor size, nuclear grade, and necrosis to predict the risk of metastasis.
Primary Source EvidenceLeibovich BC, Blute ML, Cheville JC, et al. Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma: a stratification tool for prospective clinical trials. Cancer. 2003;97(7):1663-1671.
Formula Logic
Sum of points for pT, pN, Size, Grade, Necrosis.

Reference Data

Risk GroupScore5-Year Metastasis-Free Survival
Low Risk0 - 297%
Intermediate Risk3 - 581%
High Risk≥ 668% (Score 6) to < 20% (Score >10)

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