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Clinical calculator summary

Allred Score for ER/PR

The Allred Score combines the percentage of cells that stain positive for hormone receptors (Proportion Score) with the intensity of that staining (Intensity Score).

Evidence-based context for fast calculator use

Purpose:
Allred score quantifies ER and PR hormone receptor staining in breast cancer to determine endocrine therapy eligibility and predict response.
Population:
patients undergoing breast cancer risk, staging, pathology, recurrence, or treatment-benefit assessment
Factors:
Proportion Score, Intensity Score
Reference:
Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol. 1998;11(2):155-168.
HomeAllred Score for ER/PR
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Allred Score for ER/PR

Clinical Context & Background

The Allred Score combines the percentage of cells that stain positive for hormone receptors (Proportion Score) with the intensity of that staining (Intensity Score). It is used to define ER/PR status, which is critical for determining eligibility for endocrine therapy.
Primary Source EvidenceAllred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol. 1998;11(2):155-168.
Formula Logic
Total Score (0-8) = Proportion Score (0-5) + Intensity Score (0-3)

Reference Data

Total ScoreInterpretationEndocrine Therapy
0 - 2NegativeNot Indicated
3 - 8PositiveIndicated (Benefit likely)

Clinical Workflow

Use, Interpret, And Continue The Patient Pathway

Expand for workflow guidance, limitations, examples, and related next steps.

When To Use

  • Use Allred Score for ER/PR when allred score quantifies ER and PR hormone receptor staining in breast cancer to determine endocrine therapy eligibility and predict response.
  • Confirm that the patient, diagnosis, disease phase, and available inputs match the cited model before calculation.

How To Interpret

  • Interpret the displayed result using the calculator-specific formula and reference table, spanning 0 - 2 through 3 - 8.
  • A boundary result should prompt input verification and clinical review rather than false precision.

What To Do Next

  • Integrate the result with invasive versus in-situ status, stage, receptor biology, treatment timing, genomic testing, comorbidity, and patient goals.
  • Document the inputs, result, timing, and clinical context so the assessment can be reproduced.

Limitations

  • Do not interchange screening-risk, DCIS, invasive prognosis, genomic, and post-neoadjuvant tools.
  • The result supports clinician judgment and does not independently determine treatment.

Validated Population

patients undergoing breast cancer risk, staging, pathology, recurrence, or treatment-benefit assessment

How to apply this result

For a representative case, verify Proportion Score, Intensity Score, calculate the result, and confirm that its classification matches the highlighted reference band before continuing the disease-specific pathway.

Breast Cancer hubContinue to related calculators and clinical workflow resources.

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Frequently Asked Questions

When should Allred Score for ER/PR be used?

Use it for patients undergoing breast cancer risk, staging, pathology, recurrence, or treatment-benefit assessment when all required inputs and the intended clinical setting are confirmed.

Can Allred Score for ER/PR determine treatment by itself?

No. Interpret the result with the cited evidence, complete clinical assessment, current guidelines, and patient-specific goals.

Evidence-based oncology decision support. Verify with clinical guidelines.