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SANZ Risk Score (APL)
x10⁹/L
x10⁹/L
Clinical Context & Background
The Sanz Risk Score (PETHEMA/GIMEMA) stratifies APL patients to guide treatment intensity. It is particularly crucial for determining whether patients should receive ATRA + Arsenic Trioxide (ATO) (Low/Intermediate Risk) or Cytotoxic Chemotherapy (High Risk).
Formula Logic
Based on WBC and Platelet count.Reference Data
| Risk Group | Criteria | Standard of Care |
|---|---|---|
| Low Risk | WBC ≤ 10 and Platelets > 40 | ATRA + ATO (Chemo-free) |
| Intermediate | WBC ≤ 10 and Platelets ≤ 40 | ATRA + ATO (Chemo-free) |
| High Risk | WBC > 10 | ATRA + Chemo (or ATRA+ATO+Gemtuzumab) |
Evidence-based oncology decision support. Verify with clinical guidelines.