Clinical calculator summary
Original continuous Mantle Cell Lymphoma International Prognostic Index
Clinical calculator summary
Original continuous Mantle Cell Lymphoma International Prognostic Index
A four-factor continuous prognostic equation for advanced-stage mantle cell lymphoma.
Evidence-based context for fast calculator use
- Purpose:
- Assign the source-defined low, intermediate, or high MIPI group from pretreatment values.
- Population:
- Original derivation: advanced-stage mantle cell lymphoma trial participants able to tolerate moderately intensive chemotherapy.
- Factors:
- Age, ECOG performance status, LDH relative to ULN, WBC count
- Reference:
- Hoster et al. Blood. 2008;111:558-565; erratum Blood. 2008;111:5761.
Original Continuous MIPI (Mantle Cell Lymphoma)
Clinical Context & Background
Original continuous MIPI:
WBC cells/microliter = WBC (x10^9/L) x 1000
Score = (0.03535 x age)
+ (0.6978 x I[ECOG > 1])
+ (1.367 x log10[LDH / ULN])
+ (0.9393 x log10[WBC cells/microliter])
Low risk: score < 5.7
Intermediate risk: score >= 5.7 and < 6.2
High risk: score >= 6.2Reference Data
| Risk Group | Continuous MIPI score | Historical original-cohort observation |
|---|---|---|
| Low Risk | < 5.7 | Median OS not reached; observed 5-year OS 60% |
| Intermediate Risk | >= 5.7 and < 6.2 | Median OS 51 months |
| High Risk | >= 6.2 | Median OS 29 months |
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
When To Use
- Use for baseline prognostic stratification in advanced-stage mantle cell lymphoma when all four pretreatment variables are available.
- Enter WBC in x10^9/L; the calculator converts it internally to cells/microliter for the original continuous equation.
How To Interpret
- Classify the unrounded continuous score: low <5.7, intermediate >=5.7 and <6.2, high >=6.2.
- Treat the displayed survival figures as historical original-cohort observations, not individualized current predictions.
What To Do Next
- Document the four inputs, institutional LDH ULN, full score, risk group, and any applicability warning.
- Integrate MIPI with pathology, disease extent, fitness, patient goals, and current disease-specific guidance; do not use it alone to select treatment.
Limitations
- The derivation cohort age range was 34-86 years; results outside that range carry an applicability warning.
- The model was developed in advanced-stage disease and a historical treatment era; it is not the simplified, biologic, or combined MIPI.
Validated Population
Advanced-stage mantle cell lymphoma in the original European MCL Network trial cohort; age 34-86 years.
Unit conversion matters
A WBC entry of 10 x10^9/L is converted to 10,000 cells/microliter before log10 is applied.
Calculation verification history
Verified
Calculation verification history
Verified: Production browser revalidation
- Three source-backed cases passed through visible production controls at continuous MIPI 4.11, 6.12, and 9.80.
- Low, Intermediate, and High groups rendered on first submission.
- No unexpected N/A, literal undefined value, stale control, unsupported gauge, or browser-console error was observed.
Case-level evidence is retained in validation/browser-revalidation/mipi-mantle-cell-lymphoma-index-2026-08-03.json.
: Boundary-safe display and positive laboratory guards corrected and browser-revalidated locally
- Raw scores below 5.7 or 6.2 that round to the next cutoff now display <5.70 or <6.20; exact cutoff classifications retain their ordinary display.
- LDH, LDH ULN, and WBC now visibly enforce the existing strictly-positive engine contract before calculation.
- The age-18 result rendered immediately on a fresh route load and after reset; ten visible-browser cases passed across 11 submissions and the original equation remains 241/241 verified.
Case-level local remediation evidence is retained in validation/browser-production/mipi-mantle-cell-lymphoma-index.local-remediation.json; the original production finding remains retained separately.
: Production browser validation
- Ten source-backed cases were exercised on the public production route through visible browser controls; 7/10 case records passed their expected-versus-observed assertions across 12 visible submissions.
- Overall browser status: failed-ui-and-console. high: Raw scores immediately below 5.7 and 6.2 are correctly classified using full precision but displayed as `5.70 Low Risk` and `6.20 Intermediate Risk`, contradicting the visible reference cutoffs that map >=5.7 to Intermediate and >=6.2 to High. | high: The first completed age-18 lower-bound submission produced no result and no required-field message. An immediate identical supplemental reproduction returned the correct 4.11 Low Risk result and warning. | medium: Production emitted minified React error #418 during route loads/reloads used by this run.
- Case-level inputs, expected and observed results, reset/repeat behavior, failure reproductions, and console evidence are retained in the production-browser evidence record.
Case-level production evidence is retained in validation/browser-production/mipi-mantle-cell-lymphoma-index.json.
: Browser input adapter corrected and reverified
- Accepted finite number values already normalized by the shared calculator form while retaining strict malformed-input rejection.
- No equation, cutoff, unit, classification, or applicability rule changed; calculator-specific verification and the calculator-wide browser-input audit passed.
: Full validation test
- Verified independent low, intermediate, and high cases; exact raw thresholds; all ECOG states; age guards and applicability warnings; positive laboratory domains; invalid inputs; trace; public history wiring; and displayed precision across 241 checks.
: Correction history
- Fixed the WBC unit conversion: values entered in x10^9/L are now multiplied by 1000 before log10, as required by the corrected original continuous equation.
- Removed the silent ECOG default, enforced complete valid inputs, added the age 18-120 product guard, and flagged ages outside the 34-86-year derivation cohort.
Included in the current validation report.
Verification confirms the calculator implementation against the cited model; it is not independent clinical validation, regulatory approval, or medical advice.
Frequently Asked Questions
Which MIPI version is implemented?
The original continuous four-factor MIPI. This page does not calculate simplified MIPI, MIPI-b, or MIPI-c.
What WBC unit should I enter?
Enter WBC in x10^9/L. The calculator multiplies by 1000 to obtain cells/microliter before applying the logarithmic term required by the corrected original equation.
Why is there an age applicability warning?
The original derivation cohort included ages 34-86 years. The product accepts adult ages 18-120 but flags results outside the source population.
Evidence-based oncology decision support. Verify with clinical guidelines.