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Gleason Score & ISUP Grade

Clinical Context & Background

The Gleason scoring system is the most common grading system for prostate cancer. The ISUP (International Society of Urological Pathology) Grade Group system simplifies this into 5 groups to better accurately reflect prognosis, with Group 1 being the least aggressive and Group 5 being the most aggressive.
Primary Source EvidenceEpstein JI, Egevad L, Amin MB, et al. The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. Am J Surg Pathol. 2016;40(2):244-252.
Formula Logic
Primary Pattern + Secondary Pattern = Total Score -> ISUP Group

Reference Data

ISUP GroupGleason ScoreDescription
Group 1≤ 6Clinically Indolent
Group 23 + 4 = 7Intermediate Favorable
Group 34 + 3 = 7Intermediate Unfavorable
Group 48High Risk
Group 59 - 10Highest Risk

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