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Clinical calculator summary

Decipher® Prostate Risk

The Decipher® Prostate Genomic Classifier is a 22-gene signature that predicts the risk of metastasis within 5 and 10 years after radical prostatectomy.

Evidence-based context for fast calculator use

Purpose:
Decipher Genomic Classifier interprets the 22-gene prostate cancer score to predict metastasis risk and guide adjuvant or salvage radiotherapy decisions.
Population:
patients undergoing prostate cancer diagnostic, pathologic, recurrence, or molecular-risk assessment
Factors:
Decipher Score
Reference:
Klein EA, Haddad Z, Yousefi K, et al. Decipher Genomic Classifier Measured on Prostate Biopsy Predicts Metastasis Risk. Urology. 2016;90:148-152.
HomeDecipher® Prostate Risk
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Decipher® Prostate Risk

Clinical Context & Background

The Decipher® Prostate Genomic Classifier is a 22-gene signature that predicts the risk of metastasis within 5 and 10 years after radical prostatectomy. It helps guide decisions regarding adjuvant vs. salvage radiotherapy and the addition of androgen deprivation therapy (ADT).
Primary Source EvidenceKlein EA, Haddad Z, Yousefi K, et al. Decipher Genomic Classifier Measured on Prostate Biopsy Predicts Metastasis Risk. Urology. 2016;90:148-152.
Formula Logic
Score ranges from 0 to 1.0.

Reference Data

Score RangeRisk Category10-Year Metastasis Risk (Average)
0 - 0.45Low Risk< 4%
0.46 - 0.60Intermediate Risk4% - 10%
0.61 - 1.0High Risk> 10%

Clinical Workflow

Use, Interpret, And Continue The Patient Pathway

Expand for workflow guidance, limitations, examples, and related next steps.

When To Use

  • Use Decipher® Prostate Risk when decipher Genomic Classifier interprets the 22-gene prostate cancer score to predict metastasis risk and guide adjuvant or salvage radiotherapy decisions.
  • Confirm that the patient, diagnosis, disease phase, and available inputs match the cited model before calculation.

How To Interpret

  • Interpret the displayed result using the calculator-specific formula and reference table, spanning 0 - 0.45 through 0.61 - 1.0.
  • A boundary result should prompt input verification and clinical review rather than false precision.

What To Do Next

  • Confirm biopsy versus prostatectomy setting, PSA timing, grade group, clinical/pathologic stage, imaging, life expectancy, and treatment history.
  • Document the inputs, result, timing, and clinical context so the assessment can be reproduced.

Limitations

  • Diagnostic, post-prostatectomy, genomic, and recurrence tools must be used only at their intended decision point.
  • The result supports clinician judgment and does not independently determine treatment.

Validated Population

patients undergoing prostate cancer diagnostic, pathologic, recurrence, or molecular-risk assessment

How to apply this result

For a representative case, verify Decipher Score, calculate the result, and confirm that its classification matches the highlighted reference band before continuing the disease-specific pathway.

Prostate Cancer hubContinue to related calculators and clinical workflow resources.

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Frequently Asked Questions

When should Decipher® Prostate Risk be used?

Use it for patients undergoing prostate cancer diagnostic, pathologic, recurrence, or molecular-risk assessment when all required inputs and the intended clinical setting are confirmed.

Can Decipher® Prostate Risk determine treatment by itself?

No. Interpret the result with the cited evidence, complete clinical assessment, current guidelines, and patient-specific goals.

Evidence-based oncology decision support. Verify with clinical guidelines.