Clinical calculator summary
Decipher Prostate localized reported-score interpreter
Clinical calculator summary
Decipher Prostate localized reported-score interpreter
A strict category lookup for a score already reported on a supported localized Decipher Prostate Biopsy or RP report.
Evidence-based context for fast calculator use
- Purpose:
- Preserve the submitted continuous score and display its report-defined Low, Intermediate, or High band without reproducing the proprietary assay or report outputs.
- Population:
- Localized prostatic adenocarcinoma with no pelvic radiation or hormone therapy before the source biopsy/RP specimen, using the identified Biopsy v14.0 or RP v12.0 report context.
- Factors:
- Raw externally reported score 0-1, Biopsy v14.0 versus RP v12.0, Localized disease, prior-therapy, and RP PSA coherence
- Reference:
- Veracyte. Decipher Prostate Biopsy LAB-FRM-20008 v14.0 and RP LAB-FRM-20007 v12.0 report guides. 2023-12-18.
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Decipher Prostate Localized Reported Score Interpreter
Clinical Context & Background
Enter the externally generated Decipher Prostate localized score and identify whether it comes from the supported Biopsy v14.0 or RP v12.0 report. Those two entries select the report lookup; localized prostatic adenocarcinoma, pretreatment specimen, and report-coherence requirements are shown as guidance instead of repeated questions.
Decipher Prostate is a Veracyte laboratory-developed test performed by a CLIA-certified laboratory. It has not been cleared or approved by the FDA. This route does not run the proprietary assay, derive a score, analyze genes, generate report outcomes, percentiles, probabilities, treatment benefit, or treatment choice.
Formula Logic
Localized Biopsy v14.0 and RP v12.0 reported-score lookup: score <0.45 Low; 0.45 through 0.60 inclusive Intermediate; score >0.60 High.Reference Data
| Supported localized report | Raw reported score | Reported category |
|---|---|---|
| Biopsy LAB-FRM-20008 v14.0 or RP LAB-FRM-20007 v12.0 | <0.45 | Low |
| Biopsy LAB-FRM-20008 v14.0 or RP LAB-FRM-20007 v12.0 | 0.45-0.60 inclusive | Intermediate |
| Biopsy LAB-FRM-20008 v14.0 or RP LAB-FRM-20007 v12.0 | >0.60 | High |
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
When To Use
- When a finalized Decipher Prostate localized Biopsy LAB-FRM-20008 v14.0 or RP LAB-FRM-20007 v12.0 report already provides a continuous score.
- For localized prostatic adenocarcinoma sampled before pelvic radiation or hormone therapy.
How To Interpret
- Raw score below 0.45 is Low; exactly 0.45 through exactly 0.60 is Intermediate; above 0.60 is High.
- The entered score is preserved without classification rounding or fixed-decimal replacement.
- The category is a reported-score band, not an independently calculated probability, percentile, outcome estimate, or treatment-benefit estimate.
What To Do Next
- Use the complete original Decipher report and integrate it with conventional clinical factors and current guidance outside this interpreter.
Limitations
- Regional disease is excluded pending report-version review; this route is intentionally limited to the common unambiguous localized three-band model.
- The metastatic two-band 0.85 model, Decipher GRID, unsupported specimens, and unidentified report versions are excluded.
- Does not derive the proprietary gene-expression score, genes, outcomes, percentiles, probabilities, benefit, response, or treatment selection.
- Prior pelvic radiation or hormone therapy before the source biopsy/RP specimen is outside this localized report interpretation.
Validated Population
Reported-score interpretation for localized Biopsy v14.0 and localized RP v12.0 only.
Calculation verification history
Verified
Calculation verification history
Verified: Production browser revalidation
- Three source-backed Decipher cases passed through visible production controls at Low, the exact 0.45 Intermediate boundary, and the unsupported-report Not Applicable path.
- The former unsupported-report Invalid Input disposition was absent; no unexpected N/A, literal undefined value, stale control, or browser-console error was observed.
Case-level evidence is retained in validation/browser-revalidation/prostate-cancer-decipher-genomic-2026-08-03.json.
: Local browser remediation verified
- The compact two-control adapter now accepts all four visible report dispositions before projecting the locked internal context: metastatic/other reaches Not Applicable and unknown report/version reaches Incomplete Assessment.
- Intentional unavailable results now show a Decipher-specific category-not-assigned receipt rather than generic missing-input wording.
- Ten source-backed visible-browser cases passed across eleven submissions, including both exact band boundaries, unrounded values, both supported reports, both formerly collapsed dispositions, and reset/repeat; the 482/482 source audit remains fully passing.
Case-level local remediation evidence is retained in validation/browser-production/prostate-cancer-decipher-genomic.local-remediation.json.
: Production browser validation
- Ten source-backed cases were exercised on the public production route through visible browser controls; 8/10 case records passed their expected-versus-observed assertions across 11 visible submissions.
- Overall browser status: failed-calculation-ui-and-console. high: The visible Metastatic or other report/specimen/version option returns Invalid Input instead of the source-defined Not Applicable disposition, while the visible Unknown report/version option returns Invalid Input instead of Incomplete Assessment. | medium: Production emitted minified React error #418 during the route load.
- Case-level inputs, expected and observed results, reset/repeat behavior, failure reproductions, and console evidence are retained in the production-browser evidence record.
Case-level production evidence is retained in validation/browser-production/prostate-cancer-decipher-genomic.json.
: Input workflow simplified and revalidated
- Reduced the public form to result-, branch-, unit-, and applicability-changing inputs; removed or consolidated non-scoring, administrative, and duplicate questions.
- Preserved the verified calculation or report-interpretation logic, thresholds, model version, component logic, and supported result pathways behind strict deterministic adapters.
- Passed the calculator-specific regression audit, adapter-parity and malformed-input checks, the 144-calculator input-quality audit, and the 43-calculator entry-burden audit.
: Full validation test
- 482/482 independently expected source, centesimal, continuous-boundary, malformed-input, applicability, wording, trace, UI, immutability, registry, inventory, report, history, and mirror assertions passed with zero category mismatch.
- This is source-to-code implementation verification, not independent clinical validation, individualized outcome prediction, or treatment guidance.
: Correction
- Locked the permanent route to the localized Biopsy v14 and RP v12 externally reported three-band score interpretation and disclosed the Veracyte CLIA LDT identity.
- Corrected 0.45 equality and continuous bands, removed display rounding and coercive defaults, and preserved score zero and the exact entered value.
- Added exact report, diagnosis, extent, prior-therapy, and post-RP PSA gates; excluded regional, metastatic, GRID, unsupported specimens, proprietary derivation, outcome percentages, benefits, and treatment recommendations.
Included in the current validation report.
Verification confirms the calculator implementation against the cited model; it is not independent clinical validation, regulatory approval, or medical advice.
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Frequently Asked Questions
When should Decipher Prostate Localized Reported Score Interpreter be used?
Use it for patients undergoing prostate cancer diagnostic, pathologic, recurrence, or molecular-risk assessment when all required inputs and the intended clinical setting are confirmed.
Can Decipher Prostate Localized Reported Score Interpreter determine treatment by itself?
No. Interpret the result with the cited evidence, complete clinical assessment, current guidelines, and patient-specific goals.
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