International Prognostic Score (IPS) for Hodgkin Lymphoma

The IPS identifies 7 adverse prognostic factors for advanced Hodgkin lymphoma, predicting freedom from progression to guide treatment intensity decisions.

Purpose:: Predict prognosis in advanced-stage Hodgkin lymphoma (stages III-IV)
Population:: Patients with advanced Hodgkin lymphoma (stage III-IV or bulky stage II)
Factors:: Age ≥45, Male sex, Stage IV, Albumin <4 g/dL, Haemoglobin <10.5 g/dL, WBC ≥15,000, Lymphocyte count <600 or <8%
Reference:: Hasenclever & Diehl, NEJM 1998

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IPS (Hodgkin Lymphoma)

Age ≥ 45 years?

Sex

Stage IV Disease?

Albumin < 4.0 g/dL (40 g/L)?

Hemoglobin < 10.5 g/dL?

WBC ≥ 15,000/mm³?

Lymphopenia (< 600/mm³ or < 8% of WBC)?

Clinical Context & Background

The International Prognostic Score (IPS) predicts 5-year progression-free and overall survival in patients with advanced stage (III/IV) Hodgkin Lymphoma. It counts 7 adverse risk factors.

Primary Source EvidenceHasenclever D, Diehl V. A prognostic score for advanced Hodgkin's disease. International Prognostic Factors Project on Advanced Hodgkin's Disease. N Engl J Med. 1998;339(21):1506-1514.

Formula Logic

Sum of 7 risk factors (Age, Stage, Hb, Albumin, WBC, Lymphopenia, Male).

Reference Data

Total Score	5-Year Freedom From Progression (FFP)
0	84%
1	77%
2	67%
3	60%
4	51%
≥ 5	42%

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Evidence-based oncology decision support. Verify with clinical guidelines.

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International Prognostic Score (IPS) for Hodgkin Lymphoma

IPS (Hodgkin Lymphoma)

Clinical Context & Background

Reference Data

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