Clinical calculator summary
Original 2017 CHIPS
Clinical calculator summary
Original 2017 CHIPS
A four-factor baseline prognostic score developed for pediatric and adolescent intermediate-risk classical Hodgkin lymphoma.
Evidence-based context for fast calculator use
- Purpose:
- Reproduce the original CHIPS total and source-reported historical event-free-survival rows without inventing risk groups.
- Population:
- Patients younger than 22 years with protocol-defined intermediate-risk classical Hodgkin lymphoma in the COG AHOD0031 context.
- Factors:
- Stage IV, Large mediastinal mass, Presenting fever >=38 C, Albumin <3.5 g/dL
- Reference:
- Schwartz et al. Pediatr Blood Cancer. 2017;64(4). doi:10.1002/pbc.26278.
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CHIPS (Childhood Hodgkin Score)
°C
g/dL
Clinical Context & Background
This calculator reproduces the original 2017 Childhood Hodgkin International Prognostic Score (CHIPS). One point is assigned for stage IV disease, a large mediastinal mass, presenting fever at or above 38 C, and albumin below 3.5 g/dL. Temperature and albumin are compared without rounding. Night sweats and weight loss are not CHIPS predictors.
The exact source-reported four-year event-free-survival observations were 93.1%, 88.5%, 77.6%, and 69.2% for scores 0, 1, 2, and 3. Score 4 was theoretically possible but was not observed in the original intermediate-risk cohort, so no score-specific outcome is assigned. The source also compared scores 0-1 (90.5%) with scores 2-3 (76.9%); these are source comparisons, not risk groups.
Use only for baseline context in patients younger than 22 years with protocol-defined intermediate-risk classical Hodgkin lymphoma resembling COG AHOD0031. It is not for adults, low- or high-risk disease, relapse, post-treatment or interim-PET assessment, individualized prognosis, or treatment intensification or de-escalation decisions.
Primary Source EvidenceSchwartz CL, et al. Pediatric Blood & Cancer. 2017;64(4). doi:10.1002/pbc.26278.
Formula Logic
Original 2017 CHIPS = stage IV + large mediastinal mass + presenting fever >=38 C + albumin <3.5 g/dL (1 point each; unrounded values).Reference Data
| CHIPS Score | Original 4-Year Event-Free Survival |
|---|---|
| 0 | 93.1% |
| 1 | 88.5% |
| 2 | 77.6% |
| 3 | 69.2% |
| 4 | Not observed in the original intermediate-risk cohort |
| Combined 0-1 | 90.5% (source comparison only) |
| Combined 2-3 | 76.9% (source comparison only) |
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
When To Use
- Use at diagnosis for a patient resembling the original AHOD0031 intermediate-risk population.
- Enter the unrounded presenting temperature and albumin value.
How To Interpret
- Add one point for each original adverse factor.
- Match scores 0-3 to the exact historical score-specific EFS row; score 4 has no observed source-specific EFS.
- Treat 0-1 versus 2-3 outcomes only as the source combined comparison, not invented risk groups.
What To Do Next
- Interpret the historical score with contemporary staging, response assessment, protocol criteria, and specialist judgment.
Limitations
- Not for adults, low- or high-risk disease, relapse, interim-PET or post-treatment assessment.
- Does not prescribe treatment intensification, de-escalation, or radiation decisions.
- Historical cohort observations are not individualized prognoses.
Validated Population
1,103 pediatric and adolescent patients younger than 22 years with intermediate-risk classical Hodgkin lymphoma treated on COG AHOD0031.
Calculation verification history
Verified
Calculation verification history
Verified: Production browser revalidation
- Three source-backed cases passed through visible production controls at CHIPS scores 0, 2, and 4.
- The former transient score-zero no-result defect was absent on the first completed submission.
- No unexpected N/A, literal undefined value, stale control, unsupported gauge, or browser-console error was observed.
Case-level evidence is retained in validation/browser-revalidation/chips-hodgkin-pediatric-2026-08-03.json.
: Local browser remediation
- A fresh-page score-zero submission rendered its result immediately; the calculator returns a result object for numeric zero and the shared renderer gates on that object, so no calculator-specific score-zero truthiness defect remained.
- Ten source-backed cases passed through visible local browser controls across 11 submissions, covering scores 0-4, all four factors, exact temperature and albumin transitions, the unavailable score-4 outcome, invalid albumin, and reset/repeat behavior.
- The existing calculator-specific audit passed 384/384. The earlier one-time production miss is consistent with the separately handled startup hydration condition; production revalidation remains pending deployment.
Local case-level remediation evidence is retained in validation/browser-production/chips-hodgkin-pediatric.local-remediation.json.
: Production browser validation
- Ten source-backed cases were exercised on the public production route through visible browser controls; 9/10 case records passed their expected-versus-observed assertions across 12 visible submissions.
- Overall browser status: failed-ui-and-console. high: The first completed score-0 submission produced no result and no calculator validation message. An immediate identical reproduction returned score 0 and the expected 93.1% historical row. | medium: Production emitted minified React error #418 during route loads/reloads used by this run.
- Case-level inputs, expected and observed results, reset/repeat behavior, failure reproductions, and console evidence are retained in the production-browser evidence record.
Case-level production evidence is retained in validation/browser-production/chips-hodgkin-pediatric.json.
: Full validation test
- 384/384 exhaustive scoring, exact fever/albumin boundary, strict-input, UI, trace, source-outcome, wording, immutability, registry, and no-panel checks passed with zero score or outcome mismatches.
- Scope is the original 2017 CHIPS model for patients younger than 22 years with protocol-defined intermediate-risk classical Hodgkin lymphoma in COG AHOD0031; no panel inherits this verification.
: Calculation and input-contract correction
- Replaced favorable pre-scored defaults with required semantic stage and mediastinal-mass categories, raw presenting temperature under the preserved bSymptoms input ID, and raw albumin.
- Corrected fever from >38 C to >=38 C, stopped scoring night sweats or weight loss, and enforced albumin <3.5 g/dL using unrounded values.
- Removed invented risk groups, unsupported score-4 outcome, and treatment-intensification claims; restored exact score 0-3 and combined source comparison outcomes.
Verification confirms the calculator implementation against the cited model; it is not independent clinical validation, regulatory approval, or medical advice.
Frequently Asked Questions
When should CHIPS (Childhood Hodgkin Score) be used?
Use it for patients with the specific hematologic diagnosis and disease phase described by the model when all required inputs and the intended clinical setting are confirmed.
Can CHIPS (Childhood Hodgkin Score) determine treatment by itself?
No. Interpret the result with the cited evidence, complete clinical assessment, current guidelines, and patient-specific goals.
Evidence-based oncology decision support. Verify with clinical guidelines.