CARG Toxicity Score (Geriatric)

Age ≥ 72 years?

Cancer Type: GI or GU?

Standard Dose (vs reduced)?

Polychemotherapy (multiple agents)?

Anemia (Male <11, Female <10 g/dL)?

Creatinine Clearance < 34 mL/min?

Hearing Impairment (Fair/Poor/Deaf)?

Any fall in past 6 months?

Limited in walking 1 block?

Assistance required taking meds?

Decreased social activity due to health?

Clinical Context & Background

The Cancer and Aging Research Group (CARG) Toxicity Score predicts the risk of severe (Grade 3-5) chemotherapy toxicity in older adults. It outperforms Karnofsky Performance Status (KPS) in this population by incorporating geriatric assessment variables.

Primary Source EvidenceHurria A, Togawa K, Mohile SG, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol. 2011;29(25):3457-3465.

Formula Logic

Weighted sum of 11 clinical and geriatric assessment variables.

Reference Data

Risk Group	Score	Risk of Toxicity
Low Risk	0 - 5	30%
Intermediate Risk	6 - 9	52%
High Risk	10 - 19	83%

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CARG Toxicity Score (Geriatric)

Clinical Context & Background

Reference Data

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