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Clinical calculator summary

CRASH Chemotherapy Toxicity Score

A geriatric oncology toxicity score estimating severe chemotherapy toxicity in older adults.

Evidence-based context for fast calculator use

Purpose:
Support chemotherapy toxicity risk discussion and geriatric assessment planning
Population:
Older adults being considered for chemotherapy
Factors:
Chemotox regimen risk, Diastolic blood pressure, IADL, LDH, ECOG, MMSE, MNA
Reference:
Extermann et al., Cancer 2012
HomeCRASH Chemotherapy Toxicity Score
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CRASH Chemotherapy Toxicity Score

Clinical Context & Background

The CRASH score estimates severe chemotherapy toxicity risk in older adults by combining chemotherapy-regimen toxicity risk with geriatric, laboratory, functional, nutritional, cognitive, and performance-status variables.
This implementation uses an explicit Chemotox category input. The original CRASH model used regimen toxicity estimates from the MAX2/Chemotox approach; when uncertain, use institutional oncology pharmacy input or choose the most conservative plausible category.
Formula Logic
Combined CRASH score = Chemotox category + hematologic predictors + nonhematologic predictors, counting Chemotox once. Hematologic subscore includes Chemotox, diastolic BP, IADL, and LDH. Nonhematologic subscore includes Chemotox, ECOG, MMSE, and MNA.

Reference Data

Combined ScoreRisk Category
0 - 3Low
4 - 6Intermediate-low
7 - 9Intermediate-high
> 9High

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Frequently Asked Questions

What is Chemotox in the CRASH score?

Chemotox represents chemotherapy regimen toxicity risk. The original CRASH model used an index based on regimen-level toxicity estimates. If uncertain, confirm with oncology pharmacy or use the most conservative plausible category.

How is CRASH different from CARG?

CRASH separates hematologic and nonhematologic toxicity predictors and explicitly incorporates regimen toxicity risk. CARG is often simpler to collect in routine practice.

Evidence-based oncology decision support. Verify with clinical guidelines.