Clinical calculator summary
Original Diagnosis-Specific GPA for Brain Metastases (2012)
Clinical calculator summary
Original Diagnosis-Specific GPA for Brain Metastases (2012)
A source-specific interpreter of the original non-molecular diagnosis-specific GPA branches published in 2012.
Evidence-based context for fast calculator use
- Purpose:
- Reproduce the original branch score, stratum, and historical cohort median without importing later molecular models.
- Population:
- Adults with newly diagnosed parenchymal brain metastases, no leptomeningeal disease, assessed before brain-directed treatment.
- Factors:
- Primary diagnosis branch, KPS, Age where applicable, Brain-metastasis count where applicable, Extracranial metastases for lung, Historical breast subtype
- Reference:
- Sperduto et al., J Clin Oncol. 2012;30:419-425. DOI 10.1200/JCO.2011.38.0527.
Original Diagnosis-Specific GPA for Brain Metastases (2012)
Clinical Context & Background
Original 2012 diagnosis-specific point sum (0-4) followed by source-row stratum and historical median lookup.Reference Data
| Original DS-GPA stratum | Meaning |
|---|---|
| 0.0-1.0 | Diagnosis-specific historical cohort row |
| 1.5-2.0 | Diagnosis-specific historical cohort row |
| 2.5-3.0 | Diagnosis-specific historical cohort row |
| 3.5-4.0 | Diagnosis-specific historical cohort row |
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
When To Use
- Only after confirming the exact original-model population and diagnosis branch.
- At baseline before brain-directed treatment.
How To Interpret
- Read the GPA and historical diagnosis-specific median as a cohort descriptor.
- Keep later molecular and updated GPA models separate.
What To Do Next
- Use current multidisciplinary guidance and complete clinical context outside this calculator.
Limitations
- No leptomeningeal-only or mixed leptomeningeal population.
- No pediatric, post-treatment, recurrent/progressive, unsupported-primary, or primary-CNS-tumor interpretation.
- No patient-specific prognosis or treatment selection.
Validated Population
Historical cohorts underlying the original 2012 diagnosis-specific GPA publication.
Calculation verification history
Verified
Calculation verification history
Verified: Production browser revalidation
- Three source-backed DS-GPA cases passed through visible production controls, including the explicit incomplete-scope N/A path, NSCLC minimum 0.0, and SCLC maximum 4.0.
- No unexpected N/A, literal undefined value, stale control, or browser-console error was observed.
Case-level evidence is retained in validation/browser-revalidation/brain-metastases-diagnosis-specific-gpa-2026-08-03.json.
: Production browser validation
- Ten source-backed cases were exercised on the public production route through visible browser controls; 10/10 case records passed their expected-versus-observed assertions across 11 visible submissions.
- Overall browser status: failed-console. medium: Production emitted minified React error #418 during route loads/reloads used by this run.
- Case-level inputs, expected and observed results, reset/repeat behavior, failure reproductions, and console evidence are retained in the production-browser evidence record.
Case-level production evidence is retained in validation/browser-production/brain-metastases-diagnosis-specific-gpa.json.
: Input workflow simplified and revalidated
- Reduced the public form to result-, branch-, unit-, and applicability-changing inputs; removed or consolidated non-scoring, administrative, and duplicate questions.
- Preserved the verified calculation or report-interpretation logic, thresholds, model version, component logic, and supported result pathways behind strict deterministic adapters.
- Passed the calculator-specific regression audit, adapter-parity and malformed-input checks, the 144-calculator input-quality audit, and the 43-calculator entry-burden audit.
: Model identity corrected
- Locked the permanent route to the original 2012 non-molecular Diagnosis-Specific GPA.
- Removed later Lung-molGPA, Melanoma-molGPA, and updated diagnosis-model claims.
: Calculation and applicability corrected
- Replaced defaults, coercion, mixed-version factors, clamping, and broad fallthrough with an exact immutable 11-key contract.
- Restored each original diagnosis branch, exact strata, and all six historical median tables.
- Removed treatment-selection and individualized-survival wording.
: Full validation completed
- Passed 768 of 768 deterministic assertions using a separately encoded oracle.
- Workbook and complete JSON evidence were mirrored publicly after report checks passed.
Software implementation verification only; not prospective clinical validation.
Verification confirms the calculator implementation against the cited model; it is not independent clinical validation, regulatory approval, or medical advice.
Frequently Asked Questions
When should Original Diagnosis-Specific GPA for Brain Metastases (2012) be used?
Use it for patients with primary or metastatic central nervous system disease in the setting described by the model when all required inputs and the intended clinical setting are confirmed.
Can Original Diagnosis-Specific GPA for Brain Metastases (2012) determine treatment by itself?
No. Interpret the result with the cited evidence, complete clinical assessment, current guidelines, and patient-specific goals.
Evidence-based oncology decision support. Verify with clinical guidelines.