Saved Results

No results saved yet.

Enter a patient name and hit Save on a result.

Diagnosis-Specific Graded Prognostic Assessment (DS-GPA)

The DS-GPA refines brain metastases prognosis by using tumour-specific prognostic factors that vary by primary cancer type, validated in 3,940 patients across multiple RTOG trials.

Purpose:
Provide tumour-specific survival estimates for brain metastases patients
Population:
Brain metastases patients stratified by primary cancer (NSCLC, breast, melanoma, renal, GI)
Factors:
Varies by primary: KPS, Age, Number of brain mets, Extracranial mets, Tumour subtype
Reference:
Sperduto et al., JCO 2012
HomeDiagnosis-Specific GPA (Brain Mets)
Pin your most used calculators here by clicking the star in the dropdown.

Diagnosis-Specific GPA (Brain Mets)

Clinical Context & Background

The Diagnosis-Specific Graded Prognostic Assessment (DS-GPA) is the modern standard for brain metastasis prognosis. This tool uses the updated Lung-molGPA (2017), Melanoma-molGPA (2017), Breast GPA (2020 Update), and Renal/GI GPA models.
Primary Source EvidenceSperduto PW, et al. Estimating Survival in Patients With Lung Cancer and Brain Metastases: An Update of the Graded Prognostic Assessment for Lung Cancer Using Molecular Markers (Lung-molGPA). JAMA Oncol. 2017;3(6):827–831. (See also JCO 2012, 2020).
Formula Logic
Sum of points varies by Primary Site.

Reference Data

GPA ScoreMedian Survival (Months)
0 - 1.0Poor (~ 3-6 mo)
1.5 - 2.0Intermediate (~ 9-13 mo)
2.5 - 3.0Good (~ 15-25 mo)
3.5 - 4.0Excellent (> 30 mo)

Share This Calculator

Share:

Related Tools

WHO CNS Tumor Grade (2021)RPA (Brain Metastases)GPA (Graded Prognostic Assessment)

Evidence-based oncology decision support. Verify with clinical guidelines.