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IPSET-Trombosi (Trombocitemia Essenziale)
Clinical Context & Background
L’IPSET-Trombosi originale del 2012 è un punteggio a tre gruppi. L’IPSET-Trombosi rivisto del 2015 è un albero decisionale separato a quattro categorie. Questo calcolatore mostra entrambi i risultati senza attribuire i tassi del modello originale alle categorie riviste.
Riferimenti: Barbui et al., Blood 2012; Barbui et al., Blood Cancer Journal 2015.
Formula Logic
Punti: Età > 60 (1), Anamnesi di Trombosi (2), JAK2 V617F (2), Fattori di Rischio CV (1).Reference Data
| Gruppo di Rischio | Punteggio Totale | Rischio di Trombosi (%/anno) |
|---|---|---|
| Basso | 0-1 | 1,03% |
| Intermedio | 2 | 2,35% |
| Alto | 3-6 | 3,56% |
Calculation verification history
Verified
Calculation verification history
Verified: Production browser revalidation
- Three source-backed cases passed through visible production controls at original IPSET scores 0, 2, and 6.
- Revised Very Low, Low, and High groups rendered as expected.
- No unexpected N/A, literal undefined value, stale control, unsupported gauge, or browser-console error was observed.
Case-level evidence is retained in validation/browser-revalidation/ipset-thrombosis-risk-2026-08-03.json.
: Production browser validation
- Ten source-backed cases were exercised on the public production route through visible browser controls; 10/10 case records passed their expected-versus-observed assertions across 11 visible submissions.
- Overall browser status: failed-console. medium: Production emitted minified React error #418 during route loads/reloads used by this run.
- Case-level inputs, expected and observed results, reset/repeat behavior, failure reproductions, and console evidence are retained in the production-browser evidence record.
Case-level production evidence is retained in validation/browser-production/ipset-thrombosis-risk.json.
: Full validation test
- Checked all 16 predictor combinations for both models and 15 missing, malformed, or unsupported input cases.
: Correction
- Separated the original three-tier point score from the revised four-category decision tree.
- Corrected original score groups and historical rates: 0-1 = 1.03, 2 = 2.35, and 3-6 = 3.56 events per 100 patient-years.
- Required all predictors and applied one strict engine across English, Spanish, French, German, and Italian calculators.
Included in the current validation report.
Verification confirms the calculator implementation against the cited model; it is not independent clinical validation, regulatory approval, or medical advice.
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