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Sedlis Criteria (Cervical)
Clinical Context & Background
The Sedlis Criteria identify patients with node-negative, margin-negative, parametria-negative cervical cancer who are at "Intermediate Risk" of recurrence. These patients benefit from adjuvant pelvic radiotherapy (reduced recurrence from 28% to 15%). Criteria depend on Lymphovascular Invasion (LVI), Stromal Invasion, and Tumor Size.
Formula Logic
Eligibility for RT based on combination of LVI, Depth, and Size.Reference Data
| LVI Status | Invasion Depth | Tumor Size |
|---|---|---|
| Positive (+) | Deep 1/3 | Any size |
| Positive (+) | Middle 1/3 | ≥ 2 cm |
| Positive (+) | Superficial 1/3 | ≥ 5 cm |
| Negative (-) | Deep / Middle 1/3 | ≥ 4 cm |
Evidence-based oncology decision support. Verify with clinical guidelines.