Clinical calculator summary
Sedlis Criteria for Cervical Cancer
Clinical calculator summary
Sedlis Criteria for Cervical Cancer
Intermediate-risk post-hysterectomy cervical cancer criteria using LVSI, stromal invasion depth, and tumor size.
Evidence-based context for fast calculator use
- Purpose:
- Support adjuvant pelvic radiation discussion when nodes, margins, and parametria are negative.
- Population:
- Patients with early-stage cervical cancer after radical hysterectomy and pelvic lymphadenectomy.
- Factors:
- Lymphovascular invasion, Stromal invasion depth, Tumor size, Negative nodes, Negative margins, Negative parametria
- Reference:
- Sedlis et al., Gynecol Oncol. 1999.
Sedlis Criteria (Cervical)
Clinical Context & Background
Eligibility for RT based on combination of LVI, Depth, and Size.Reference Data
| LVI Status | Invasion Depth | Tumor Size |
|---|---|---|
| Positive (+) | Deep 1/3 | Any size |
| Positive (+) | Middle 1/3 | ≥ 2 cm |
| Positive (+) | Superficial 1/3 | ≥ 5 cm |
| Negative (-) | Deep / Middle 1/3 | ≥ 4 cm |
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
When To Use
- Use after radical hysterectomy and pelvic lymphadenectomy for early-stage cervical cancer when final pathology is available.
- Apply only after high-risk features such as positive nodes, positive margins, or parametrial involvement have been excluded.
- Most useful for deciding whether intermediate-risk features support adjuvant pelvic radiation discussion.
How To Interpret
- Criteria met means the combination of LVSI, stromal invasion depth, and tumor size fits an intermediate-risk Sedlis pattern.
- Criteria not met supports observation in the appropriate node-negative, margin-negative, parametria-negative context.
- The result should be interpreted with histology, surgical quality, fertility/ovarian considerations, radiation toxicity, and local guideline context.
What To Do Next
- Verify negative nodes, margins, and parametria before using the low/intermediate-risk pathway.
- If high-risk Peters criteria are present, move to the high-risk postoperative cervical cancer pathway rather than using Sedlis alone.
- Discuss radiation benefits and morbidity in a multidisciplinary gynecologic oncology and radiation oncology setting.
Limitations
- Do not use for patients with positive nodes, positive margins, parametrial involvement, unresected disease, or definitive chemoradiation planning.
- The tool is not a FIGO staging calculator and does not replace full postoperative guideline review.
- Tumor size, LVSI, and invasion depth must be taken from reliable final pathology.
Validated Population
Early-stage cervical cancer after radical hysterectomy and pelvic lymphadenectomy with negative nodes, negative margins, and negative parametria.
Example use
A patient with LVSI-positive disease, middle-third stromal invasion, and a 2.5 cm tumor meets Sedlis intermediate-risk criteria; the next step is adjuvant pelvic radiation discussion after confirming no high-risk Peters features.
Related Tools
Frequently Asked Questions
What assumptions are required before applying Sedlis Criteria?
Sedlis Criteria are intended for node-negative, margin-negative, parametria-negative cervical cancer after radical hysterectomy and pelvic lymphadenectomy.
Do Sedlis Criteria replace high-risk cervical cancer criteria?
No. Positive nodes, positive margins, or parametrial involvement are high-risk features and should be managed using guideline-based high-risk postoperative pathways.
Evidence-based oncology decision support. Verify with clinical guidelines.