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HomeROMA Score (Ovarian)
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ROMA Score (Ovarian)

Clinical Context & Background

The Risk of Ovarian Malignancy Algorithm (ROMA) combines Serum HE4, CA125, and menopausal status to calculate the predictive probability of finding epithelial ovarian cancer. It is typically more sensitive than RMI for detecting early-stage disease. This calculator uses the Roche Elecsys formula.
Primary Source EvidenceMoore RG, McMeekin DS, Brown AK, et al. A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass. Gynecol Oncol. 2009;112(1):40-46.
Formula Logic
Complex logistic regression dependent on menopausal status.

Reference Data

GroupCut-offRisk
Premenopausal< 11.4%Low Risk
Premenopausal≥ 11.4%High Risk
Postmenopausal< 29.9%Low Risk
Postmenopausal≥ 29.9%High Risk

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