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NET Grade / WHO 2019
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Clinical Context & Background
The WHO Classification of Neuroendocrine Neoplasms (NENs) grades tumors based on proliferative activity, measured by Ki-67 index or Mitotic Count. This grading is critical for prognosis and treatment selection. If Ki-67 and Mitotic Count are discordant, the higher grade is assigned.
Formula Logic
Grade determined by higher of Ki-67 or Mitoses.Reference Data
| Grade | Mitotic Count (/2mm²) | Ki-67 Index |
|---|---|---|
| G1 (Low Grade) | < 2 | < 3% |
| G2 (Intermediate) | 2 - 20 | 3 - 20% |
| G3 (High Grade) | > 20 | > 20% |
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