Clinical calculator summary
Original Mariani Mayo Low-Risk Criteria
Clinical calculator summary
Original Mariani Mayo Low-Risk Criteria
A six-condition historical surgicopathologic rule for a selected endometrioid corpus-cancer subset.
Evidence-based context for fast calculator use
- Purpose:
- Reproduce the original 2000 Mayo low-risk classification without converting it into a probability or treatment directive.
- Population:
- Surgically assessed endometrioid carcinoma of the uterine corpus without gross extrauterine disease.
- Factors:
- Histology, FIGO grade, Myometrial invasion, Greatest tumor surface dimension, Gross extrauterine disease, Assessment context
- Reference:
- Mariani et al. Am J Obstet Gynecol. 2000;182(6):1506-1519.
Mayo Criteria (Endometrial)
Clinical Context & Background
Original 2000 Mariani Mayo low-risk criteria are met only for endometrioid corpus carcinoma with FIGO grade 1 or 2, raw myometrial invasion <=50%, raw greatest tumor surface dimension <=2 cm, no gross extrauterine disease, and adequate surgicopathologic assessment.Reference Data
| Source criterion | Required finding |
|---|---|
| Histology | Endometrioid carcinoma of the uterine corpus |
| FIGO grade | Grade 1 or 2 |
| Myometrial invasion | <=50% using the raw value |
| Greatest tumor surface dimension | <=2 cm using the raw value |
| Gross extrauterine disease | Absent |
| Assessment | Adequate surgicopathologic assessment |
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
When To Use
- Use only for endometrioid carcinoma of the uterine corpus with adequate surgicopathologic assessment.
- Confirm grade, raw invasion percentage, greatest surface dimension, and absence of gross extrauterine disease.
How To Interpret
- Criteria met means every original Mariani condition is satisfied.
- Criteria not met is not a blanket high-risk category.
- Histology, gross disease, or assessment context outside the source subset is reported as not applicable.
What To Do Next
- Document the raw pathology measurements and assessment context.
- Integrate sentinel-node staging, molecular classification, LVSI, histology, contemporary guidelines, and multidisciplinary review.
Limitations
- Do not apply automatically to non-endometrioid tumors, biopsy-only or imaging-only estimates, recurrent disease, or metastatic disease.
- Historical cohort observations are not individualized probabilities.
- The result does not prescribe or omit nodal assessment or another treatment.
Validated Population
Selected surgically treated grade 1-2 endometrioid corpus carcinoma with <=50% invasion and no gross extrauterine disease in the original Mayo cohort.
Raw boundary example
Endometrioid grade 2 disease with exactly 50% invasion and exactly 2.0 cm greatest surface dimension qualifies when all eligibility conditions are satisfied; 50.0001% or 2.0001 cm does not.
Calculation verification history
Verified
Calculation verification history
Verified: Production browser revalidation
- Three source-backed cases passed through visible production controls across minimum, exact upper boundaries, and grade-3 failure.
- The former literal undefined trace defect was absent.
- No unexpected N/A, literal undefined value, stale control, unsupported gauge, or browser-console error was observed.
Case-level evidence is retained in validation/browser-revalidation/mayo-endometrial-cancer-metastasis-2026-08-03.json.
: Local browser remediation verification
- Ten source-backed cases passed through visible local browser controls across 11 submissions after the shared result-trace correction.
- The run covered minimum values, exact inclusive boundaries, both just-over transitions, grade 3, maximum invasion, gross-disease and unconfirmed-eligibility exclusions, required-field validation, and reset/repeat behavior.
- Every completed result displayed six defined criteria rows with no literal undefined or NaN. The original production findings remain open until deployment and public revalidation.
Case-level local remediation evidence is retained in validation/browser-production/mayo-endometrial-cancer-metastasis.local-remediation.json.
: Production browser validation found a presentation defect
- Ten source-backed cases were entered through visible production controls across 11 Calculate attempts; all ten top-level classifications or input dispositions matched the original Mayo rule.
- Nine of ten UI cases failed because every rendered completed result trace displayed literal undefined for all six criteria decisions, including valid, not-applicable, seed, and repeated calculations.
- Exact 50% and 2.0 cm boundaries, just-over-limit transitions, eligibility exclusions, required-field feedback, and reset clearing were otherwise correct; production also emitted React hydration error #418.
Exact case-level reproductions are retained in validation/browser-production/mayo-endometrial-cancer-metastasis.json.
: Browser input adapter corrected and reverified
- Accepted finite number values already normalized by the shared calculator form while retaining strict malformed-input rejection.
- No equation, cutoff, unit, classification, or applicability rule changed; calculator-specific verification and the calculator-wide browser-input audit passed.
: Input workflow simplified and revalidated
- Reduced the public form to result-, branch-, unit-, and applicability-changing inputs; removed or consolidated non-scoring, administrative, and duplicate questions.
- Preserved the verified calculation or report-interpretation logic, thresholds, model version, component logic, and supported result pathways behind strict deterministic adapters.
- Passed the calculator-specific regression audit, adapter-parity and malformed-input checks, the 144-calculator input-quality audit, and the 43-calculator entry-burden audit.
: Full validation test
- 384/384 source-rule, raw-boundary, applicability, malformed-input, UI, trace, scope, report, registry, and isolation checks passed.
- No registered master panel calculates this Mayo endometrial rule; no panel receives inherited verification.
: Calculation and input-contract correction
- Replaced favorable categorical defaults with six explicit fields, raw invasion 0-100% and positive size measurements, strict missing/extra/type validation, and exact 50% and 2 cm boundaries.
- Added histology, gross-disease, and assessment-context applicability gates; corrected the publication citation; removed unsupported risk percentages, blanket high-risk labels, and automatic lymphadenectomy or sentinel-node advice.
Verification confirms the calculator implementation against the cited model; it is not independent clinical validation, regulatory approval, or medical advice.
Related Tools
Frequently Asked Questions
Do exactly 50% invasion and 2.0 cm satisfy the criteria?
Yes. The original rule uses no more than 50% myometrial invasion and a greatest surface dimension no more than 2 cm. Classification uses raw, unrounded values.
Does criteria not met mean high risk?
No. It means only that an otherwise eligible endometrioid case does not satisfy every original low-risk condition. The rule does not quantify all alternative cases.
Does criteria met mean nodal assessment should be omitted?
No. The calculator reproduces a historical classification and does not prescribe or omit lymphadenectomy or sentinel-node mapping.
Evidence-based oncology decision support. Verify with clinical guidelines.