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Mayo Criteria (Endometrial)

Clinical Context & Background

The Mayo Clinic criteria identify patients with low-risk endometrial cancer who have a very low risk of lymph node metastasis. In these patients, systematic lymphadenectomy may be safely omitted to reduce morbidity (lymphedema).
Primary Source EvidenceMariani A, Webb MJ, Keeney GL, et al. Low-risk corpus cancer: is lymphadenectomy always necessary? Gynecol Oncol. 2000;78(1):13-19.
Formula Logic
Low risk if: Grade 1-2, Myometrial invasion ≤ 50%, Tumor size ≤ 2 cm.

Reference Data

CriteriaRisk of LN MetastasisRecommendation
Met All< 1%Lymphadenectomy may be omitted
Failed Any> 5-10%Lymphadenectomy (or SLN) recommended

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