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Clinical calculator summary

MASCC Febrile Neutropenia Risk Index

A complication-risk index for adults presenting with febrile neutropenia.

Evidence-based context for fast calculator use

Purpose:
Identify patients who may be low risk after urgent febrile-neutropenia assessment
Population:
Adults with treatment-related febrile neutropenia after immediate clinical stabilization and infection assessment
Factors:
Illness burden, Hypotension, COPD, Tumor type, Dehydration, Outpatient status, Age
Reference:
Klastersky et al., J Clin Oncol. 2000
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MASCC Risk Index

Clinical Context & Background

The Multinational Association for Supportive Care in Cancer (MASCC) risk index identifies patients with chemotherapy-induced febrile neutropenia who have a low risk of complications. These patients may be eligible for outpatient management and oral antibiotics.
Primary Source EvidenceKlastersky J, Paesmans M, Rubenstein EB, et al. The Multinational Association for Supportive Care in Cancer risk index: A multinational scoring system for identifying low-risk febrile neutropenic cancer patients. J Clin Oncol. 2000;18(16):3038-3051.
Formula Logic
Sum of points (Max 26). Score ≥ 21 indicates low risk.

Reference Data

Risk GroupScoreManagement
Low Risk≥ 21 pointsConsider outpatient management with oral antibiotics.
High Risk< 21 pointsInpatient admission and IV antibiotics required.

Clinical Workflow

Use, Interpret, And Continue The Patient Pathway

Expand for workflow guidance, limitations, examples, and related next steps.

When To Use

  • Use during initial febrile-neutropenia assessment after urgent observations, sepsis evaluation, cultures, and empiric-antibiotic planning.
  • Use only when the patient and clinical setting match the population described for MASCC Febrile Neutropenia Risk Index.

How To Interpret

  • A score of 21 or more identifies a lower complication-risk group but does not by itself establish outpatient safety.
  • Interpret thresholds with the entered units, current clinical status, and local guideline context.

What To Do Next

  • Confirm clinical stability, oral intake, organ function, social support, travel time, follow-up access, and local antimicrobial pathway.
  • Document the inputs, result, clinical judgment, and any reason for deviating from the model-guided pathway.

Limitations

  • Never delay empiric antibiotics or override sepsis physiology because of a favorable score.
  • This calculator supports clinical assessment and does not independently prescribe treatment.

Validated Population

Adults with treatment-related febrile neutropenia after immediate clinical stabilization and infection assessment

Clinical example

A MASCC score above 21 in a stable patient supports outpatient-pathway consideration only after all clinical and logistical exclusion criteria are checked.

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Frequently Asked Questions

What is MASCC Febrile Neutropenia Risk Index used for?

Identify patients who may be low risk after urgent febrile-neutropenia assessment. It is intended for adults with treatment-related febrile neutropenia after immediate clinical stabilization and infection assessment.

Does MASCC Febrile Neutropenia Risk Index determine treatment by itself?

No. Confirm the population, inputs, contraindications, competing risks, and current guideline recommendations before acting on the result.

Evidence-based oncology decision support. Verify with clinical guidelines.