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Clinical calculator summary

CISNE Febrile Neutropenia Score

A serious-complication score for apparently stable adults with solid tumors and febrile neutropenia.

Evidence-based context for fast calculator use

Purpose:
Refine risk assessment within clinically stable solid-tumor febrile neutropenia
Population:
Apparently stable adults with solid tumors and treatment-related febrile neutropenia
Factors:
ECOG status, COPD, Cardiovascular disease, Mucositis, Monocytes, Stress hyperglycemia
Reference:
Carmona-Bayonas et al., J Clin Oncol. 2015
HomeCISNE Score (Febrile Neutropenia)
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CISNE Score (Febrile Neutropenia)

Clinical Context & Background

The CISNE score predicts the risk of serious complications in patients with solid tumors and apparently stable febrile neutropenia (FN). It complements the MASCC index by specifically stratifying risk within the "stable" subgroup, helping identify those truly safe for outpatient care.
Primary Source EvidenceCarmona-Bayonas A, Jiménez-Fonseca P, Virizuela Echaburu J, et al. Prediction of serious complications in patients with seemingly stable febrile neutropenia: validation of the Clinical Index of Stable Febrile Neutropenia (CISNE). J Clin Oncol. 2015;33(5):465-471.
Formula Logic
Sum of points for ECOG, COPD, CV disease, Mucositis, Monocytes, and Hyperglycemia.

Reference Data

Risk ClassScoreComplication Rate
Low Risk01.1%
Intermediate1 - 26.2%
High Risk≥ 336%

Clinical Workflow

Use, Interpret, And Continue The Patient Pathway

Expand for workflow guidance, limitations, examples, and related next steps.

When To Use

  • Use only after confirming apparent clinical stability in a patient with a solid tumor and febrile neutropenia.
  • Use only when the patient and clinical setting match the population described for CISNE Febrile Neutropenia Score.

How To Interpret

  • Increasing scores identify greater serious-complication risk; CISNE is not designed to rescue an unstable patient into outpatient care.
  • Interpret thresholds with the entered units, current clinical status, and local guideline context.

What To Do Next

  • Combine with MASCC, sepsis assessment, infection focus, organ function, oral tolerance, support, and reliable follow-up.
  • Document the inputs, result, clinical judgment, and any reason for deviating from the model-guided pathway.

Limitations

  • Do not apply to hematologic malignancy, obvious instability, or as a reason to delay antibiotics.
  • This calculator supports clinical assessment and does not independently prescribe treatment.

Validated Population

Apparently stable adults with solid tumors and treatment-related febrile neutropenia

Clinical example

A patient who appears stable but has ECOG 2, COPD, and mucositis accumulates CISNE risk and should not be considered low risk from appearance alone.

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Related Tools

MASCC Risk IndexFebrile Neutropenia TriageKhorana Score (VTE Risk)

Frequently Asked Questions

What is CISNE Febrile Neutropenia Score used for?

Refine risk assessment within clinically stable solid-tumor febrile neutropenia. It is intended for apparently stable adults with solid tumors and treatment-related febrile neutropenia.

Does CISNE Febrile Neutropenia Score determine treatment by itself?

No. Confirm the population, inputs, contraindications, competing risks, and current guideline recommendations before acting on the result.

Evidence-based oncology decision support. Verify with clinical guidelines.