Clinical calculator summary
Original and Revised IPSET-Thrombosis
Clinical calculator summary
Original and Revised IPSET-Thrombosis
Two distinct thrombosis-risk models for WHO-defined essential thrombocythemia.
Evidence-based context for fast calculator use
- Purpose:
- Report the original point score and revised four-category classification without conflating them.
- Population:
- Patients with confirmed WHO-defined essential thrombocythemia and known predictor status
- Factors:
- Age >60 years, Previous major thrombosis, JAK2 V617F, Cardiovascular risk factors
- Reference:
- Barbui et al., Blood 2012; Barbui et al., Blood Cancer J 2015.
IPSET-Thrombosis (Essential Thrombocythemia)
Clinical Context & Background
Original IPSET: age >60 (+1), prior thrombosis (+2), JAK2 V617F (+2), cardiovascular risk factors (+1). Revised IPSET: four-category decision tree using age >60, prior thrombosis, and JAK2 V617F.Reference Data
| Model | Criteria | Result |
|---|---|---|
| Original | Score 0-1 | Low; 1.03 events per 100 patient-years |
| Original | Score 2 | Intermediate; 2.35 events per 100 patient-years |
| Original | Score 3-6 | High; 3.56 events per 100 patient-years |
| Revised | Age ≤60, no thrombosis, JAK2-unmutated | Very low |
| Revised | Age ≤60, no thrombosis, JAK2-mutated | Low |
| Revised | Age >60, no thrombosis, JAK2-unmutated | Intermediate |
| Revised | Prior thrombosis, or age >60 plus JAK2-mutated | High |
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
When To Use
- Use IPSET-Thrombosis (Essential Thrombocythemia) when calculate both the original 2012 IPSET-Thrombosis score and the revised 2015 IPSET-Thrombosis category for WHO-defined essential thrombocythemia.
- Confirm that the patient, diagnosis, disease phase, and available inputs match the cited model before calculation.
How To Interpret
- Interpret the displayed result using the calculator-specific formula and reference table, spanning Original through Revised.
- A boundary result should prompt input verification and clinical review rather than false precision.
What To Do Next
- Confirm morphology, molecular/cytogenetic data, treatment timing, laboratory units, and the current disease-specific guideline before acting.
- Document the inputs, result, timing, and clinical context so the assessment can be reproduced.
Limitations
- Hematology scores are diagnosis-, phase-, and treatment-specific and should not be transferred between diseases.
- The result supports clinician judgment and does not independently determine treatment.
Validated Population
patients with the specific hematologic diagnosis and disease phase described by the model
How to apply this result
For a representative case, verify Age > 60 years?, Previous major arterial or venous thrombosis?, JAK2 V617F detected?, calculate the result, and confirm that its classification matches the highlighted reference band before continuing the disease-specific pathway.
Calculation verification history
Verified
Calculation verification history
Verified: Production browser revalidation
- Three source-backed cases passed through visible production controls at original IPSET scores 0, 2, and 6.
- Revised Very Low, Low, and High groups rendered as expected.
- No unexpected N/A, literal undefined value, stale control, unsupported gauge, or browser-console error was observed.
Case-level evidence is retained in validation/browser-revalidation/ipset-thrombosis-risk-2026-08-03.json.
: Production browser validation
- Ten source-backed cases were exercised on the public production route through visible browser controls; 10/10 case records passed their expected-versus-observed assertions across 11 visible submissions.
- Overall browser status: failed-console. medium: Production emitted minified React error #418 during route loads/reloads used by this run.
- Case-level inputs, expected and observed results, reset/repeat behavior, failure reproductions, and console evidence are retained in the production-browser evidence record.
Case-level production evidence is retained in validation/browser-production/ipset-thrombosis-risk.json.
: Full validation test
- Checked all 16 predictor combinations for both models and 15 missing, malformed, or unsupported input cases.
: Correction
- Separated the original three-tier point score from the revised four-category decision tree.
- Corrected original score groups and historical rates: 0-1 = 1.03, 2 = 2.35, and 3-6 = 3.56 events per 100 patient-years.
- Required all predictors and applied one strict engine across English, Spanish, French, German, and Italian calculators.
Included in the current validation report.
Verification confirms the calculator implementation against the cited model; it is not independent clinical validation, regulatory approval, or medical advice.
Related Tools
Frequently Asked Questions
Why are two IPSET results shown?
The original IPSET is a point score with three categories and cohort event rates. Revised IPSET is a separate decision tree with four categories. They are not interchangeable.
Does cardiovascular risk change revised IPSET?
No. It contributes one point to original IPSET but does not change the revised category. Cardiovascular risks remain clinically important.
Evidence-based oncology decision support. Verify with clinical guidelines.