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HomeHScore for HLH
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HScore for HLH

Clinical Context & Background

The HScore is a validated tool to estimate the probability of secondary HLH in adults. It incorporates clinical, biologic, and cytologic features. A score > 169 correlates with a > 93% sensitivity and > 86% specificity for HLH.
Primary Source EvidenceFardet L, et al. Development and validation of the HScore, a score for the diagnosis of hemophagocytic lymphohistiocytosis. Arthritis Rheumatol. 2014;66(9):2613-2620.
Formula Logic
Sum of weighted points for 9 variables.

Reference Data

HScoreProbability of HLH
< 90< 1%
90 - 169Low to Intermediate
169~ 70% cutoff
> 200> 98%

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