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Clinical calculator summary

GRIm Score

The GRIm Score is a prognostic score developed to predict overall survival in patients treated with immune checkpoint inhibitors (specifically in Phase I trials).

Evidence-based context for fast calculator use

Purpose:
GRIm Score predicts overall survival on immune checkpoint inhibitors using albumin, LDH, and NLR to select immunotherapy candidates.
Population:
patients undergoing lung cancer immunotherapy or prognostic assessment
Factors:
Albumin < 35 g/L?, LDH > Upper Limit of Normal?, Neutrophil-to-Lymphocyte Ratio> 6?
Reference:
Bigot F, et al. The Gustave Roussy Immune Score (GRIm-Score) predicts survival in patients treated with immunotherapy in phase I trials. Eur J Cancer. 2017;84:212-218.
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GRIm Score

Clinical Context & Background

The GRIm Score is a prognostic score developed to predict overall survival in patients treated with immune checkpoint inhibitors (specifically in Phase I trials). It serves as a selection tool to identify patients who are more likely to benefit from immunotherapy.
Primary Source EvidenceBigot F, et al. The Gustave Roussy Immune Score (GRIm-Score) predicts survival in patients treated with immunotherapy in phase I trials. Eur J Cancer. 2017;84:212-218.
Formula Logic
Sum of 3 risk factors: Albumin < 35 g/L, LDH > ULN, NLR > 6.

Reference Data

Total ScorePrognosis
0 - 1Low Risk (Better Survival)
2 - 3High Risk (Poorer Survival)

Clinical Workflow

Use, Interpret, And Continue The Patient Pathway

Expand for workflow guidance, limitations, examples, and related next steps.

When To Use

  • Use GRIm Score when gRIm Score predicts overall survival on immune checkpoint inhibitors using albumin, LDH, and NLR to select immunotherapy candidates.
  • Confirm that the patient, diagnosis, disease phase, and available inputs match the cited model before calculation.

How To Interpret

  • Interpret the displayed result using the calculator-specific formula and reference table, spanning 0 - 1 through 2 - 3.
  • A boundary result should prompt input verification and clinical review rather than false precision.

What To Do Next

  • Integrate the result with histology, molecular profile, stage, treatment line, imaging, and performance status.
  • Document the inputs, result, timing, and clinical context so the assessment can be reproduced.

Limitations

  • Do not transfer an immunotherapy or laboratory prognostic score to an unvalidated treatment setting.
  • The result supports clinician judgment and does not independently determine treatment.

Validated Population

patients undergoing lung cancer immunotherapy or prognostic assessment

How to apply this result

For a representative case, verify Albumin < 35 g/L?, LDH > Upper Limit of Normal?, Neutrophil-to-Lymphocyte Ratio> 6?, calculate the result, and confirm that its classification matches the highlighted reference band before continuing the disease-specific pathway.

Lung Cancer & IO hubContinue to related calculators and clinical workflow resources.

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Frequently Asked Questions

When should GRIm Score be used?

Use it for patients undergoing lung cancer immunotherapy or prognostic assessment when all required inputs and the intended clinical setting are confirmed.

Can GRIm Score determine treatment by itself?

No. Interpret the result with the cited evidence, complete clinical assessment, current guidelines, and patient-specific goals.

Evidence-based oncology decision support. Verify with clinical guidelines.