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Clinical calculator summary

CLIP Score

The CLIP score integrates tumor characteristics (morphology, AFP, portal vein thrombosis) with liver function (Child-Pugh stage) to provide a prognostic stratification for patients with HCC.

Evidence-based context for fast calculator use

Purpose:
CLIP score estimates hepatocellular carcinoma survival by integrating Child-Pugh stage, tumor morphology, AFP, and portal vein thrombosis status.
Population:
patients undergoing liver-function, hepatocellular carcinoma staging, imaging, or transplant assessment
Factors:
Child-Pugh Stage, Tumor Morphology, Alpha-Fetoprotein, Portal Vein Thrombosis
Reference:
The Cancer of the Liver Italian Program (CLIP) investigators. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients. Hepatology. 1998;28(3):751-755.
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CLIP Score

Clinical Context & Background

The CLIP score integrates tumor characteristics (morphology, AFP, portal vein thrombosis) with liver function (Child-Pugh stage) to provide a prognostic stratification for patients with HCC. It is often considered more accurate than Okuda staging.
Primary Source EvidenceThe Cancer of the Liver Italian Program (CLIP) investigators. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients. Hepatology. 1998;28(3):751-755.
Formula Logic
Sum of points (0-6) from Child-Pugh, Tumor Morphology, AFP, and PVT.

Reference Data

Total ScoreMedian Survival
042 months
132 months
222 months
313 months
412 months
5 - 65 months

Clinical Workflow

Use, Interpret, And Continue The Patient Pathway

Expand for workflow guidance, limitations, examples, and related next steps.

When To Use

  • Use CLIP Score when cLIP score estimates hepatocellular carcinoma survival by integrating Child-Pugh stage, tumor morphology, AFP, and portal vein thrombosis status.
  • Confirm that the patient, diagnosis, disease phase, and available inputs match the cited model before calculation.

How To Interpret

  • Interpret the displayed result using the calculator-specific formula and reference table, spanning 0 through 5 - 6.
  • A boundary result should prompt input verification and clinical review rather than false precision.

What To Do Next

  • Integrate liver reserve, portal hypertension, tumor burden, vascular invasion, extrahepatic disease, performance status, and transplant policy.
  • Document the inputs, result, timing, and clinical context so the assessment can be reproduced.

Limitations

  • Liver function, HCC stage, imaging category, and transplant criteria are complementary but not interchangeable.
  • The result supports clinician judgment and does not independently determine treatment.

Validated Population

patients undergoing liver-function, hepatocellular carcinoma staging, imaging, or transplant assessment

How to apply this result

For a representative case, verify Child-Pugh Stage, Tumor Morphology, Alpha-Fetoprotein, calculate the result, and confirm that its classification matches the highlighted reference band before continuing the disease-specific pathway.

Liver / HCC hubContinue to related calculators and clinical workflow resources.

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Frequently Asked Questions

When should CLIP Score be used?

Use it for patients undergoing liver-function, hepatocellular carcinoma staging, imaging, or transplant assessment when all required inputs and the intended clinical setting are confirmed.

Can CLIP Score determine treatment by itself?

No. Interpret the result with the cited evidence, complete clinical assessment, current guidelines, and patient-specific goals.

Evidence-based oncology decision support. Verify with clinical guidelines.