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Clinical calculator summary

ALBI Score

The Albumin-Bilirubin (ALBI) grade is an objective, evidence-based method for assessing liver function in patients with Hepatocellular Carcinoma (HCC).

Evidence-based context for fast calculator use

Purpose:
ALBI score grades hepatocellular carcinoma liver function using albumin and bilirubin levels to stratify prognosis and guide HCC treatment.
Population:
patients undergoing liver-function, hepatocellular carcinoma staging, imaging, or transplant assessment
Factors:
Total Bilirubin, Albumin
Reference:
Johnson PJ, Berhane S, Kagebayashi C, et al. Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade. J Clin Oncol. 2015;33(6):550-558.
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ALBI Score

µmol/L
g/L

Clinical Context & Background

The Albumin-Bilirubin (ALBI) grade is an objective, evidence-based method for assessing liver function in patients with Hepatocellular Carcinoma (HCC). Unlike the Child-Pugh score, it relies solely on albumin and bilirubin levels, eliminating subjective variables like ascites and encephalopathy. ALBI offers a more granular assessment of liver function and is a strong prognostic factor for overall survival.
Primary Source EvidenceJohnson PJ, Berhane S, Kagebayashi C, et al. Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade. J Clin Oncol. 2015;33(6):550-558.
Formula Logic
(log₁₀(bilirubin [µmol/L]) × 0.66) + (albumin [g/L] × -0.085)

Reference Data

ALBI GradeScore CutoffPrognosis
Grade 1≤ -2.60Good Prognosis
Grade 2> -2.60 to ≤ -1.39Intermediate Prognosis
Grade 3> -1.39Poor Prognosis

Clinical Workflow

Use, Interpret, And Continue The Patient Pathway

Expand for workflow guidance, limitations, examples, and related next steps.

When To Use

  • Use ALBI Score when aLBI score grades hepatocellular carcinoma liver function using albumin and bilirubin levels to stratify prognosis and guide HCC treatment.
  • Confirm that the patient, diagnosis, disease phase, and available inputs match the cited model before calculation.

How To Interpret

  • Interpret the displayed result using the calculator-specific formula and reference table, spanning Grade 1 through Grade 3.
  • A boundary result should prompt input verification and clinical review rather than false precision.

What To Do Next

  • Integrate liver reserve, portal hypertension, tumor burden, vascular invasion, extrahepatic disease, performance status, and transplant policy.
  • Document the inputs, result, timing, and clinical context so the assessment can be reproduced.

Limitations

  • Liver function, HCC stage, imaging category, and transplant criteria are complementary but not interchangeable.
  • The result supports clinician judgment and does not independently determine treatment.

Validated Population

patients undergoing liver-function, hepatocellular carcinoma staging, imaging, or transplant assessment

How to apply this result

For a representative case, verify Total Bilirubin, Albumin, calculate the result, and confirm that its classification matches the highlighted reference band before continuing the disease-specific pathway.

Liver / HCC hubContinue to related calculators and clinical workflow resources.

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Frequently Asked Questions

When should ALBI Score be used?

Use it for patients undergoing liver-function, hepatocellular carcinoma staging, imaging, or transplant assessment when all required inputs and the intended clinical setting are confirmed.

Can ALBI Score determine treatment by itself?

No. Interpret the result with the cited evidence, complete clinical assessment, current guidelines, and patient-specific goals.

Evidence-based oncology decision support. Verify with clinical guidelines.