Clinical calculator summary
Carboplatin Calvert Formula Calculator
Clinical calculator summary
Carboplatin Calvert Formula Calculator
AUC-based total carboplatin dose from target exposure and absolute kidney function.
Evidence-based context for fast calculator use
- Purpose:
- Support protocol-specific independent carboplatin dose verification
- Population:
- Adults older than 18 years receiving a protocol that specifies AUC-based carboplatin dosing
- Factors:
- Protocol target AUC, Kidney-function method and stability, BSA conversion when indexed, Protocol-specific cap policy
- Reference:
- Calvert et al., J Clin Oncol 1989; ADDIKD 2022; eviQ calculator 4171
Carboplatin Calvert Formula Dose
Required for the adult-use boundary and Cockcroft-Gault calculation when that method is selected.
Enter the target AUC specified by the governing regimen; the calculator does not choose it.
Clinical Context & Background
Total dose (mg) = target AUC × (absolute kidney function [mL/min] + 25). Indexed eGFR is converted as eGFR × BSA / 1.73. Only the final dose is rounded.Reference Data
| Decision | Current evidence | Calculator behavior |
|---|---|---|
| Kidney function | Directly measured GFR preferred | Exact mL/min value used |
| Estimated eGFR | Eligible indexed CKD-EPI 45-125, non-curative intent, suitable body composition | Converted to absolute mL/min using selected BSA equation |
| 125 mL/min cap | ADDIKD: no cap; some protocols: cap | Explicit protocol choice required |
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
Clinical Workflow
Use, Interpret, And Continue The Patient Pathway
Expand for workflow guidance, limitations, examples, and related next steps.
When To Use
- Use when a carboplatin-containing protocol specifies a target AUC and the required kidney-function method and cap policy are known.
- Use only when the patient and clinical setting match the population described for Carboplatin Calvert Formula.
How To Interpret
- The output is a total milligram dose, not mg/m², and depends directly on absolute kidney function in mL/min.
- Interpret thresholds with the entered units, current clinical status, and local guideline context.
What To Do Next
- Verify regimen AUC, kidney-function source and stability, any BSA conversion, protocol cap policy, toxicity adjustments, and independent pharmacy dose check.
- Document the inputs, result, clinical judgment, and any reason for deviating from the model-guided pathway.
Limitations
- Estimated kidney function may be unreliable with unstable renal function, curative intent, extreme body composition, amputation, paraplegia, skeletal-muscle conditions, or non-standardized creatinine assays.
- This calculator supports clinical assessment and does not independently prescribe treatment.
Validated Population
Adults receiving carboplatin when a regimen-specific target AUC and appropriate stable kidney-function value are available
Clinical example
At target AUC 5 and measured GFR 75 mL/min, the Calvert equation gives a total dose of 500 mg before protocol-specific verification.
Calculation verification history
Verified
Calculation verification history
Verified: Production browser revalidation
- Five source-backed measured-GFR cases were exercised on the public production route through visible controls; 5/5 expected Calvert doses matched, including the explicit 125 mL/min cap transition.
- No unexpected N/A, literal undefined value, stale control, or browser-console error was observed.
Case-level evidence is retained in validation/browser-revalidation/carboplatin-calvert-formula-dose-2026-08-03.json.
: Production browser validation
- Ten source-backed cases were exercised on the public production route through visible browser controls; 10/10 case records passed their expected-versus-observed assertions across 11 visible submissions.
- Overall browser status: failed-console. medium: Production emitted minified React error #418 during route loads/reloads used by this run.
- Case-level inputs, expected and observed results, reset/repeat behavior, failure reproductions, and console evidence are retained in the production-browser evidence record.
Case-level production evidence is retained in validation/browser-production/carboplatin-calvert-formula-dose.json.
: Full validation test
- Passed 77/77 formula, final-rounding, kidney-method, BSA conversion, Cockcroft-Gault weight-basis, cap-policy, applicability, missing-input, and malformed-input checks.
- Confirmed exact Calvert results and zero maximum absolute kidney-function difference across independent fixtures.
: Correction
- Separated directly measured GFR, eligible BSA-adjusted CKD-EPI eGFR, and protocol-authorized Cockcroft-Gault creatinine clearance instead of treating them as interchangeable.
- Required explicit kidney-function stability, method, weight basis where applicable, and protocol-specific cap policy; removed favorable defaults.
- Converted indexed eGFR to absolute mL/min before dosing and enforced the eviQ eligibility range and context.
- Removed the unsupported universal 900 mg warning and made no-cap versus 125 mL/min cap guidance transparent.
Included in the current validation report.
Verification confirms the calculator implementation against the cited model; it is not independent clinical validation, regulatory approval, or medical advice.
Popular Tools
Frequently Asked Questions
Is the result in mg/m²?
No. The Calvert formula gives a total dose in milligrams.
Should kidney function be capped at 125 mL/min?
Current ADDIKD guidance recommends no cap, but some FDA/NCI-style protocols retain one. Select the policy required by the governing regimen and pharmacy.
Evidence-based oncology decision support. Verify with clinical guidelines.