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Clinical calculator summary

Carboplatin Calvert Formula Calculator

AUC-based carboplatin dosing formula using target exposure and kidney function.

Evidence-based context for fast calculator use

Purpose:
Support regimen-specific carboplatin dose calculation
Population:
Patients being considered for carboplatin where AUC-based dosing is used
Factors:
Target AUC, GFR or creatinine clearance, GFR cap policy, Cockcroft-Gault assumptions
Reference:
Calvert et al., J Clin Oncol 1989; FDA/NCI carboplatin dosing guidance
HomeCarboplatin Calvert Formula Dose
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Carboplatin Calvert Formula Dose

Clinical Context & Background

The Calvert formula estimates total carboplatin dose in milligrams from target AUC and kidney function: Dose = target AUC x (GFR + 25). The original formula used measured GFR; in practice, many protocols use creatinine clearance or other kidney-function estimates.
This calculator supports either direct GFR/CrCl entry or Cockcroft-Gault estimation. Because institutional protocols differ on measured GFR, estimated kidney function, serum creatinine rounding, and GFR capping, verify the result against the regimen protocol, pharmacy policy, and current renal dosing guidance before prescribing.
Formula Logic
Total dose (mg) = target AUC x (GFR + 25). Optional cap applies GFR/CrCl maximum of 125 mL/min before calculating the dose.

Reference Data

Target AUCTypical Context
AUC 4-6Common range for many single-agent or combination protocols; confirm regimen-specific target
GFR cap 125 mL/minCommon FDA/NCI-style maximum-dose convention; institutional practice may differ
Measured GFRPreferred when estimates are unreliable or accurate therapeutic dosing is critical

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Frequently Asked Questions

Is the Calvert formula dose in mg/m2?

No. The Calvert formula calculates total carboplatin dose in milligrams, not mg/m2.

Should GFR be capped at 125 mL/min?

Some FDA/NCI-style guidance caps GFR at 125 mL/min to limit high calculated doses, but some modern kidney-dosing guidance and institutions may not cap. Follow the regimen protocol and pharmacy policy.

Evidence-based oncology decision support. Verify with clinical guidelines.