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Clinical calculator summary

MACIS Score (Thyroid)

The MACIS score (Metastasis, Age, Completeness of resection, Invasion, Size) predicts cause-specific survival in patients with papillary thyroid cancer.

Evidence-based context for fast calculator use

Purpose:
MACIS Score estimates 20-year cause-specific survival in papillary thyroid carcinoma to guide postoperative risk stratification decisions.
Population:
patients with differentiated thyroid cancer pathology in the staging or recurrence-risk setting described by the model
Factors:
Age, Tumor Size, Completeness of Resection, Local Invasion?, Distant Metastasis?
Reference:
Hay ID, Bergstralh EJ, Goellner JR, Ebersold JR, Grant CS. Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989. Surgery. 1993;114(6):1050-1057.
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MACIS Score (Thyroid)

years
cm

Clinical Context & Background

The MACIS score (Metastasis, Age, Completeness of resection, Invasion, Size) predicts cause-specific survival in patients with papillary thyroid cancer. It is one of the most reliable prognostic scoring systems for well-differentiated thyroid cancer.
Primary Source EvidenceHay ID, Bergstralh EJ, Goellner JR, Ebersold JR, Grant CS. Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989. Surgery. 1993;114(6):1050-1057.
Formula Logic
Score = 3.1 (if age < 40) or 0.08 x age (if ≥ 40) + 0.3 x size (cm) + 1 (if incompletely resected) + 1 (if locally invasive) + 3 (if distant mets).

Reference Data

Score20-Year Survival
< 6.099%
6.0 - 6.989%
7.0 - 7.956%
≥ 8.024%

Clinical Workflow

Use, Interpret, And Continue The Patient Pathway

Expand for workflow guidance, limitations, examples, and related next steps.

When To Use

  • Use MACIS Score (Thyroid) when mACIS Score estimates 20-year cause-specific survival in papillary thyroid carcinoma to guide postoperative risk stratification decisions.
  • Confirm that the patient, diagnosis, disease phase, and available inputs match the cited model before calculation.

How To Interpret

  • Interpret the displayed result using the calculator-specific formula and reference table, spanning < 6.0 through ≥ 8.0.
  • A boundary result should prompt input verification and clinical review rather than false precision.

What To Do Next

  • Confirm histology, age, tumor size, invasion, nodal and distant disease, resection status, molecular findings, and guideline system.
  • Document the inputs, result, timing, and clinical context so the assessment can be reproduced.

Limitations

  • Mortality staging, recurrence-risk classification, and postoperative response assessment are different frameworks.
  • The result supports clinician judgment and does not independently determine treatment.

Validated Population

patients with differentiated thyroid cancer pathology in the staging or recurrence-risk setting described by the model

How to apply this result

For a representative case, verify Age, Tumor Size, Completeness of Resection, calculate the result, and confirm that its classification matches the highlighted reference band before continuing the disease-specific pathway.

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ATA Risk Stratification (Thyroid)

Frequently Asked Questions

When should MACIS Score (Thyroid) be used?

Use it for patients with differentiated thyroid cancer pathology in the staging or recurrence-risk setting described by the model when all required inputs and the intended clinical setting are confirmed.

Can MACIS Score (Thyroid) determine treatment by itself?

No. Interpret the result with the cited evidence, complete clinical assessment, current guidelines, and patient-specific goals.

Evidence-based oncology decision support. Verify with clinical guidelines.