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FNCLCC Grade (Soft Tissue Sarcoma)
Clinical Context & Background
The FNCLCC (Fédération Nationale des Centres de Lutte Contre le Cancer) grading system is the most widely used system for grading soft tissue sarcomas. It predicts metastasis-free and overall survival based on three parameters: Tumor Differentiation, Mitotic Count, and Tumor Necrosis.
Formula Logic
Sum of Differentiation (1-3) + Mitosis (1-3) + Necrosis (0-2).Reference Data
| Total Score | Grade | Biological Behavior |
|---|---|---|
| 2 - 3 | Grade 1 | Low Grade (Well differentiated, slow growth) |
| 4 - 5 | Grade 2 | Intermediate Grade |
| 6 - 8 | Grade 3 | High Grade (Poorly differentiated, aggressive) |
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