Original DIPSS for Primary Myelofibrosis
Source-locked guide to the original 2010 all-age DIPSS model for confirmed primary myelofibrosis.
What this calculator implements
This calculator implements the original all-age Dynamic International Prognostic Scoring System (DIPSS) described by Passamonti and colleagues in 2010 for confirmed primary myelofibrosis. Unlike the baseline IPSS, DIPSS can be reassessed during the disease course.
Exact scoring
- Age older than 65 years: 1 point
- Persistent hemoglobin below 10 g/dL (100 g/L), not caused by treatment toxicity: 2 points
- White blood cell count above 25 x 10^9/L: 1 point
- Peripheral blood blasts at least 1%: 1 point
- At least one constitutional symptom: 1 point
Constitutional symptoms are weight loss greater than 10% in 6 months, night sweats, or unexplained fever above 37.5 C. For longitudinal use, anemia must be persistent and not caused by treatment toxicity; other newly acquired factors should be disease-related.
| Score | Group | Historical median overall survival | | ---: | --- | --- | | 0 | Low | Median not reached | | 1-2 | Intermediate-1 | 14.2 years | | 3-4 | Intermediate-2 | 4.0 years | | 5-6 | High | 1.5 years |
These are historical original-cohort observations. Interpret them using elapsed time since diagnosis and only until the risk category changes. They are not individualized contemporary survival estimates.
Population and exclusions
Use the original DIPSS only for confirmed primary myelofibrosis. Do not apply this implementation to post-polycythemia-vera MF, post-essential-thrombocythemia MF, prefibrotic MF, treatment-toxicity-induced anemia, or predictors acquired for reasons unrelated to the disease.
No continuous hard minimum or maximum is added for age or laboratory values because the source does not define operational ranges beyond the published thresholds.
Related models are different
Baseline IPSS, age-adjusted DIPSS, DIPSS-Plus, MIPSS70 variants, and MYSEC-PM have different populations, variables, weights, or purposes. A result from this standalone calculator does not validate or substitute for those models.
Clinical interpretation
DIPSS is a prognostic aid, not a treatment or transplant directive. Document the assessment date and all five inputs, reassess when clinically appropriate, and make management decisions using the full clinical context and current guidance.
Open the original DIPSS calculator
Primary sources
- Passamonti F, Cervantes F, Vannucchi AM, et al. A dynamic prognostic model to predict survival in primary myelofibrosis. Blood. 2010;115(9):1703-1708. Primary publication
- PubMed record